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\u9234\u9e7f\u533b\u7642\u79d1\u5b66\u5927\u5b66 \u85ac\u5b66\u90e8<\/a> \u6559\u6388
\n\u90e1\u5c71 \u6075\u6a39\u69d8<\/p>\n

\u9234\u9e7f\u533b\u7642\u79d1\u5b66\u5927\u5b66 \u85ac\u5b66\u90e8\u3067\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u7d42\u672b\u7cd6\u5316\u7269\u8cea\u306e\u795e\u7d4c\u969c\u5bb3\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u305d\u306e\u7814\u7a76\u5185\u5bb9\u306b\u3064\u3044\u3066\u6559\u6388 \u90e1\u5c71 \u6075\u6a39\u69d8\u306b\u8a73\u3057\u304f\u304a\u8a71\u3092\u304a\u4f3a\u3044\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u7814\u7a76\u5185\u5bb9<\/h2>\n

\u7de8\u96c6\u90e8\uff1a\u300c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u7d42\u672b\u7cd6\u5316\u7269\u8cea\u306e\u795e\u7d4c\u969c\u5bb3\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7814\u7a76\u300d\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u5185\u5bb9\u3068\u7814\u7a76\u7d50\u679c\u306b\u3064\u3044\u3066\u304a\u4f3a\u3044\u3057\u3066\u3082\u3088\u308d\u3057\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/p>\n

\u90e1\u5c71\u69d8\uff1a<\/strong>\u7cd6\u5c3f\u75c5\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u7d042\u500d\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u8840\u4e2d\u306b\u306f\u3001\u8272\u3005\u306a\u7a2e\u985e\u306e\u7cd6\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u53cd\u5fdc\u3057\u3066\u4f5c\u3089\u308c\u308b\u7d42\u672b\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u304c\u591a\u304f\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u305f\u304f\u3055\u3093\u306e\u7cd6\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5165\u3063\u305f\u98df\u6750\u3092\u52a0\u71b1\u3057\u305f\u3068\u304d\u306b\u8910\u8272\u306b\u5909\u5316\u3057\u307e\u3059\u304c\u3001\u305d\u306e\u300c\u304a\u3053\u3052\u300d\u304cAGEs\u3067\u3042\u308a\u3001\u7cd6\u304c\u591a\u3044\u4f53\u5185\u306b\u304a\u3044\u3066\u3082\u305f\u304f\u3055\u3093\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u300c\u304a\u3053\u3052\u300d\u304c\u3067\u304d\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

\u6211\u3005\u306f\u3001AGEs\u3092\u7523\u751f\u3057\u3046\u308b\u7cd6\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u3068\u547c\u3070\u308c\u308b\u7cd6\u304b\u3089\u3064\u304f\u3089\u308c\u308bAGEs\u304c\u8133\u306b\u5bfe\u3057\u3066\u5f37\u529b\u306a\u6bd2\u6027\u3092\u793a\u3059\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002
\n\u307e\u305f\u3001\u5171\u540c\u7814\u7a76\u8005\u3067\u3042\u308b\u91d1\u6ca2\u533b\u79d1\u5927\u5b66\u306e\u7af9\u5185\u6b63\u7fa9\u6559\u6388\u306f\u3001\u305d\u306e\u3053\u3068\u304b\u3089\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u7531\u6765\u306eAGEs\u3092\u3001\u6bd2\u6027AGEs\uff08TAGE\uff09\u3068\u5b9a\u7fa9\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4e00\u65b9\u3001\u306a\u305c\u7cd6\u5c3f\u75c5\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u3092\u4fc3\u9032\u3055\u305b\u308b\u306e\u304b\u3001\u8a73\u7d30\u306a\u4f5c\u7528\u6a5f\u5e8f\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002
\n\u6211\u3005\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u8133\u5185\u3067\u306f\u5927\u91cf\u306eTAGE\u304c\u4f5c\u3089\u308c\u3066\u3044\u3066\u3001\u795e\u7d4c\u7d30\u80de\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001TAGE\u306b\u3088\u308b\u8133\u306e\u795e\u7d4c\u7d30\u80de\u6bd2\u6027\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u767a\u75c7\u306e\u95a2\u9023\u6027\u3092\u8abf\u3079\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u8133\u306f\u305f\u304f\u3055\u3093\u306e\u795e\u7d4c\u7d30\u80de\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u795e\u7d4c\u7d30\u80de\u306f\u8fd1\u63a5\u3059\u308b\u795e\u7d4c\u7d30\u80de\u3069\u3046\u3057\u3067\u8ef8\u7d22\u3068\u3044\u3046\u8155\u3092\u4f38\u3070\u3057\u3001\u60c5\u5831\u3092\u76f8\u4e92\u306b\u9001\u308a\u3042\u3063\u3066\u8a18\u61b6\u3084\u5b66\u7fd2\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u307e\u305f\u3001\u4e00\u822c\u7684\u306b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8133\u306e\u795e\u7d4c\u7d30\u80de\u5185\u90e8\u3067\u306f\u3001\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u3068\u3044\u3046\u300c\u795e\u7d4c\u8ef8\u7d22\u306e\u3082\u3064\u308c\u300d\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u6b63\u3057\u3044\u60c5\u5831\u306e\u3084\u308a\u53d6\u308a\u304c\u3067\u304d\u306a\u3044\u72b6\u614b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6211\u3005\u306f\u3001\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u8ef8\u7d22\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3066TAGE\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u6b63\u3057\u3044\u8ef8\u7d22\u306e\u5f62\u6210\u304c\u90aa\u9b54\u3055\u308c\u308b\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002
\n\u795e\u7d4c\u304c\u8ef8\u7d22\u3092\u4f38\u3070\u3055\u306a\u304f\u306a\u308c\u3070\u3001\u795e\u7d4c\u306e\u60c5\u5831\u306e\u3084\u308a\u3068\u308a\u306b\u7570\u5e38\u304c\u751f\u3058\u308b\u306e\u3067\u3001\u305d\u308c\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u539f\u56e0\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002
\n\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u8133\u795e\u7d4c\u7d30\u80de\u306e\u5185\u90e8\u3067\u89b3\u5bdf\u3055\u308c\u308b\u3001TAGE\u306e\u84c4\u7a4d\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u795e\u7d4c\u539f\u7dda\u7dad\u5909\u5316\u3068\u975e\u5e38\u306b\u3088\u304f\u4f3c\u3066\u304a\u308a\u3001\u305d\u306e\u539f\u56e0\u306e\u3072\u3068\u3064\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7814\u7a76\u3092\u59cb\u3081\u305f\u304d\u3063\u304b\u3051<\/strong><\/h2>\n

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\u307e\u305f\u30011970\u5e74\u4ee3\u306e\u7c73\u56fd\u306b\u304a\u3044\u3066\u3001\u5927\u91cf\u306e\u30c8\u30a6\u30e2\u30ed\u30b3\u30b7\u304b\u3089\u7570\u6027\u5316\u7cd6\u306e\u4eba\u5de5\u5408\u6210\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\u7d50\u679c\u3001\u679c\u7cd6\u30d6\u30c9\u30a6\u7cd6\u6db2\u7cd6\u304c\u98df\u6587\u5316\u3092\u5927\u304d\u304f\u5909\u5316\u3055\u305b\u3001\u305d\u306e\u5f8c\u306e\u6210\u4eba\u80a5\u6e80\u7387\u4e0a\u6607\u306b\u7d9a\u3044\u3066\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u6570\u306e\u5897\u52a0\u3068\u8a8d\u77e5\u75c7\u60a3\u8005\u6570\u304c\u5897\u3048\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002
\n\u3057\u304b\u3057\u3001\u305d\u308c\u3089\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u8a73\u7d30\u306b\u8aac\u660e\u3057\u305f\u8ad6\u6587\u5831\u544a\u304c\u5c11\u306a\u3044\u3053\u3068\u3092\u77e5\u308a\u3001\u3053\u306e\u7814\u7a76\u306b\u7740\u624b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u7814\u7a76\u306e\u610f\u7fa9<\/strong><\/h2>\n

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\u90e1\u5c71\u69d8\uff1a<\/strong>\u6211\u3005\u306f\u3001\u679c\u7cd6\u30d6\u30c9\u30a6\u7cd6\u6db2\u7cd6\u304b\u3089\u751f\u6210\u3055\u308c\u3084\u3059\u3044\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u306b\u3088\u3063\u3066\u3001\u8ef8\u7d22\u3092\u69cb\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u300c\u304a\u3053\u3052\u300d\u304c\u3001\u795e\u7d4c\u8ef8\u7d22\u306e\u300c\u3082\u3064\u308c\u300d\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u767a\u75c7\u306e\u539f\u56e0\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3044\u307e\u3059\u3002
\n\u305d\u306e\u300c\u304a\u3053\u3052\u300d\u3084\u300c\u3082\u3064\u308c\u300d\u3092\u8efd\u6e1b\u3042\u308b\u3044\u306f\u56de\u907f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u3084\u9032\u884c\u6291\u5236\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eca\u5f8c\u306e\u76ee\u6a19<\/strong><\/h2>\n

\u7de8\u96c6\u90e8\uff1a\u4eca\u5f8c\u306f\u3069\u3046\u3044\u3063\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u304f\u65b9\u91dd\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/strong><\/p>\n

\u90e1\u5c71\u69d8\uff1a<\/strong>\u3053\u308c\u307e\u3067\u57f9\u990a\u7d30\u80de\u30e2\u30c7\u30eb\u3092\u4f7f\u3063\u305f\u30c7\u30fc\u30bf\u53ce\u96c6\u304c\u4e3b\u3067\u3057\u305f\u3002
\n\u6211\u3005\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u5b9f\u9a13\u52d5\u7269\u3092\u7528\u3044\u3066\u8133\u795e\u7d4c\u7d30\u80de\u306e\u8ef8\u7d22\u304c\u4f38\u3073\u308b\u69d8\u5b50\u3092\u89b3\u5bdf\u3067\u304d\u308b\u72ec\u81ea\u6280\u8853\u3092\u4fdd\u6709\u3057\u3066\u304a\u308a\u307e\u3059\u3002
\n\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5f97\u3089\u308c\u3066\u304d\u305f\u77e5\u898b\u306b\u3064\u3044\u3066\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u4f7f\u3063\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\u3068\u3053\u308d\u3067\u3059\u3002
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\n\u3057\u304b\u3057\u3001\u30b0\u30ea\u30bb\u30eb\u30a2\u30eb\u30c7\u30d2\u30c9\u53ca\u3073TAGE\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u767a\u75c7\u306e\u65e9\u671f\u8a3a\u65ad\u3084\u767a\u75c7\u30fb\u9032\u884c\u306e\u4e88\u6e2c\u3092\u53ef\u80fd\u3068\u3059\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u8ca2\u732e\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\u53c2\u8003\u6587\u732e
\nKoriyama Y, Furukawa A, Muramatsu M, Takino J, Takeuchi M. Glyceraldehyde caused Alzheimer’s disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells. Sci Rep. 5:13313. 2015<\/p>\n

Nasu R, Furukawa A, Suzuki K, Takeuchi M, Koriyama Y. The Effect of Glyceraldehyde-Derived Advanced Glycation End Products on \u03b2-Tubulin-Inhibited Neurite Outgrowth in SH-SY5Y Human Neuroblastoma Cells. Nutrients, 12:2958. 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

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