{"id":22806,"date":"2022-06-30T01:00:56","date_gmt":"2022-06-29T16:00:56","guid":{"rendered":"https:\/\/www.mcsg.co.jp\/kentatsu\/?p=22806"},"modified":"2023-05-10T21:23:11","modified_gmt":"2023-05-10T12:23:11","slug":"%e3%80%90%e5%b0%82%e9%96%80%e5%ae%b6%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%93%e3%83%a5%e3%83%bc%e3%80%91bdnf%e3%82%92%e8%a7%a3%e6%98%8e%e3%81%97%e3%80%81%e8%aa%8d%e7%9f%a5%e7%97%87%e3%81%ae%e6%b2%bb","status":"publish","type":"post","link":"https:\/\/www.mcsg.co.jp\/kentatsu\/interview\/22806","title":{"rendered":"\u3010\u5c02\u9580\u5bb6\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u3011BDNF\u3092\u89e3\u660e\u3057\u3001\u8a8d\u77e5\u75c7\u306e\u6cbb\u7642\u85ac\u30fb\u4e88\u9632\u85ac\u3092\u958b\u767a\u3059\u308b"},"content":{"rendered":"

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\n\u4f8b\u3048\u3070\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u3044\u3063\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3001\u3046\u3064\u75c5\u3084\u7d71\u5408\u5931\u8abf\u75c7\u306a\u3069\u306e\u7cbe\u795e\u75be\u60a3\u306e\u60a3\u8005\u6b7b\u5f8c\u8133\u3092\u7528\u3044\u305f\u7814\u7a76\u3067\u306f\u3001\u8133\u5185BDNF\u767a\u73fe\u91cf\u304c\u3053\u308c\u3089\u75be\u60a3\u306b\u304a\u3044\u3066\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001BDNF\u306f\u69d8\u3005\u306a\u8133\u30fb\u795e\u7d4c\u7cfb\u306e\u75be\u60a3\u306e\u5275\u85ac\u7814\u7a76\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u5206\u5b50\u306e1\u3064\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

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\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u79c1\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3051\u308bBDNF\u306e\u767a\u73fe\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002<\/span>\u307e\u305f\u3001\u3053\u306e\u7814\u7a76\u306e\u904e\u7a0b\u3067\u3001\u5171\u540c\u7814\u7a76\u8005\u306e\u529b\u3092\u501f\u308a\u306a\u304c\u3089\u3001\u751f\u304d\u305f\u307e\u307e\u8133\u5185\u306eBDNF\u306e\u767a\u73fe\u5909\u5316\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u30de\u30a6\u30b9\u3092\u4f5c\u51fa\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u3055\u3089\u306b\u3001\u3053\u306e\u30de\u30a6\u30b9\u3092\u5fdc\u7528\u3057\u3066\u3001\u795e\u7d4c\u7d30\u80de\u3067BDNF\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u85ac\u3092\u7c21\u5358\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u65b9\u6cd5\u3082\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u3044\u305a\u308c\u306e\u65b9\u6cd5\u3082\u5b9f\u9a13\u52d5\u7269\u3084\u57f9\u990a\u7d30\u80de\u3092\u4f7f\u3063\u305f\u57fa\u790e\u6bb5\u968e\u306e\u7814\u7a76\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u65b9\u6cd5\u3092\u99c6\u4f7f\u3057\u3066\u8a8d\u77e5\u75c7\u8133\u5185\u3067\u306eBDNF\u306e\u6642\u7a7a\u9593\u7684\u5909\u5316\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u307e\u305f\u8133\u5185BDNF\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u85ac\u304c\u958b\u767a\u3067\u304d\u308c\u3070\u3001\u5c06\u6765\u7684\u306b\u306f\u8a8d\u77e5\u75c7\u306e\u6cbb\u7642\u85ac\u3084\u4e88\u9632\u85ac\u306e\u958b\u767a\u306e\u4e00\u52a9\u306b\u306a\u308b\u3068\u4fe1\u3058\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\uff08\u53c2\u8003\u6587\u732e\uff09<\/span><\/p>\n

Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M. Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice. Sci Rep. 7:4949. 2017<\/span><\/a><\/p>\n

Fukuchi M, Okuno Y, Nakayama H, Nakano A, Mori H, Mitazaki S, Nakano Y, Toume K, Jo M, Takasaki I, Watanabe K, Shibahara N, Komatsu K, Tabuchi A, Tsuda M. Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice. Sci Rep. 9:11833. 2019<\/span><\/a><\/p>\n

Fukuchi M, Saito R, Maki S, Hagiwara N, Nakajima Y, Mitazaki S, Izumi H, Mori H. Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging. Mol Brain. 13:122. 2020<\/span><\/a><\/p>\n

\u7de8\u96c6\u90e8\uff1aBDNF\u4ee5\u5916\u306e\u8133\u30fb\u795e\u7d4c\u7cfb\u306e\u6a5f\u80fd\u767a\u73fe\u306b\u91cd\u8981\u306a\u56e0\u5b50\u306b\u95a2\u3059\u308b\u7814\u7a76\u3082\u884c\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u304c\u3001\u3053\u3061\u3089\u3082\u8a8d\u77e5\u75c7\u4e88\u9632\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3067\u3057\u3087\u3046\u304b\uff1f\u3088\u308d\u3057\u3051\u308c\u3070\u5177\u4f53\u7684\u306a\u7814\u7a76\u5185\u5bb9\u3082\u4f3a\u3048\u308c\u3070\u5e78\u3044\u3067\u3059\u3002<\/strong><\/p>\n

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