{"id":71904,"date":"2024-02-01T12:33:19","date_gmt":"2024-02-01T03:33:19","guid":{"rendered":"https:\/\/www.mcsg.co.jp\/kentatsu\/?p=71904"},"modified":"2025-07-23T11:38:50","modified_gmt":"2025-07-23T02:38:50","slug":"%e6%be%a4%e7%94%b0-%e6%a8%b9%e4%bd%b3-52","status":"publish","type":"post","link":"https:\/\/www.mcsg.co.jp\/kentatsu\/interview\/71904","title":{"rendered":"\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u6442\u53d6\u306b\u671f\u5f85\u3055\u308c\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e88\u9632\u52b9\u679c"},"content":{"rendered":"

\u6297\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u52b9\u679c\u3092\u5f37\u304f\u793a\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u304c\u3042\u308b<\/h2>\n

\u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u75be\u60a3\u306e\u904e\u534a\u6570\u3092\u5360\u3081\u308b\u306e\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u3059\u3002
\n\u98df\u54c1\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u6297\u9178\u5316\u4f5c\u7528\u306a\u3069\u306e\u6297\u8a8d\u77e5\u75c7\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u308f\u305f\u3057\u305f\u3061\u306f\u98df\u54c1\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u985e\u306e\u6297\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u52b9\u679c\u306b\u3064\u3044\u3066\u3001\u8a66\u9a13\u7ba1\u5185\u30e2\u30c7\u30eb\u304a\u3088\u3073\u52d5\u7269\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u3001\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f<\/span>1)2)3)<\/span>\u3002<\/span><\/p>\n

\u307e\u305f\u3001\u308f\u305f\u3057\u305f\u3061\u306f\u3082\u3063\u3068\u3082\u5f37\u3044\u6297\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u52b9\u679c\u3092\u793a\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3067\u3042\u308b\u300c\u30ed\u30b9\u30de\u30ea\u30f3\u9178<\/span>\uff3b\u56f3\uff11\uff21\uff3d<\/span><\/strong>\u300d\u306b\u7740\u76ee\u3057\u3001\u305d\u308c\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u300c\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\uff08Melissa officinalis\uff09<\/span>\uff3b\u56f3\uff11\uff22\uff3d<\/b><\/span>\u300d\u306e\u62bd\u51fa\u7269\u304b\u3089\u3001\u30ab\u30d7\u30bb\u30eb<\/span>\uff3b\u56f3\uff11\uff23\uff3d<\/span><\/strong>\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\uff3b\u56f3\uff11\uff21\uff3d\u30ed\u30b9\u30de\u30ea\u30f3\u9178\uff08\u69cb\u9020\u5f0f\uff09<\/b><\/span><\/p>\n

\"\"<\/p>\n

\uff3b\u56f3\uff11\uff22\uff3d\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\uff08\u5199\u771f\uff09<\/b><\/span><\/p>\n

\"\"<\/p>\n

\uff3b\u56f3\uff11\uff23\uff3d\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u30ab\u30d7\u30bb\u30eb\uff08\u5199\u771f\uff09<\/b><\/span><\/p>\n

\"\"<\/p>\n

\u307e\u305a\u3001\u5065\u5e38\u8005\u306b\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u30ab\u30d7\u30bb\u30eb\u3092\u6295\u4e0e\u3057\u3001\u5b89\u5168\u6027\u3068\u85ac\u7269\u52d5\u614b\u3092\u78ba\u8a8d\u3057\u305f\u5f8c<\/span>4)<\/span>\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u306b\u300148\u9031\u9593\u306e\u9023\u7d9a\u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f<\/span>5)<\/span>\u3002
\n<\/span><\/p>\n

\u305d\u3057\u3066\u3001\u975e\u8a8d\u77e5\u75c7\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u300196\u9031\u9593\u9023\u7d9a\u6295\u4e0e\u306e\u8a8d\u77e5\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u691c\u8a3c\u306e\u305f\u3081\u306e\u81e8\u5e8a\u8a66\u9a13\u3092\u884c\u3044\u307e\u3057\u305f<\/span>6)<\/span>\u3002<\/span><\/p>\n

\u672c\u7a3f\u3067\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3055\u3093\u3001\u304a\u3088\u3073\u975e\u8a8d\u77e5\u75c7\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306b\u3064\u3044\u3066\u6982\u8aac\u3057\u307e\u3059\u3002<\/span><\/p>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3055\u3093\u304c\u5bfe\u8c61\u306e\u8a66\u9a13\u3067\u306f\u3001\u884c\u52d5\u30fb\u5fc3\u7406\u75c7\u72b6\u304c\u6539\u5584<\/h2>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u300160\u6b73\u4ee5\u4e0a\u3067\u8a3a\u65ad\u57fa\u6e96\u3092\u6e80\u305f\u3059\u3001\u8efd\u5ea6\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u306b\u3057\u307e\u3057\u305f\u3002
\n\u9069\u683c\u57fa\u6e96\u3092\u6e80\u305f\u3059\u65b9\u3092\u3001\u5b9f\u85ac\u7fa4\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u3064\u3051\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u309224\u9031\u9593\u9023\u7d9a\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u3008\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3009\u306f\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269 \uff08\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3068\u3057\u3066500 mg\/\u65e5\uff09\u306e\u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u5fcd\u5bb9\u6027\u3001\u3008\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3009\u306f\u3001\u8a8d\u77e5\u6a5f\u80fd\u3084\u8a8d\u77e5\u75c7\u306e\u884c\u52d5\u30fb\u5fc3\u7406\u75c7\u72b6\uff08\u8a8d\u77e5\u6a5f\u80fd\u304c\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u3067\u751f\u3058\u308b\u3053\u3068\u306e\u3042\u308b\u3001\u3055\u307e\u3056\u307e\u306a\u75c7\u72b6\u3002\u5984\u60f3\u3084\u5e7b\u899a\u3001\u4e0d\u5b89\u3001\u7761\u7720\u969c\u5bb3\u306a\u3069\uff09\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3068\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u672c\u7814\u7a76\u306e\u5b9f\u65bd\u306b\u3042\u305f\u3063\u3066\u306f\u3001\u91d1\u6ca2\u5927\u5b66\u533b\u5b66\u502b\u7406\u5be9\u67fb\u59d4\u54e1\u4f1a\uff08932\u53f7\uff09\u306e\u627f\u8a8d\u3092\u53d7\u3051\u307e\u3057\u305f\uff08\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\uff1aUMIN 000007734\uff09\u3002<\/span><\/p>\n

 <\/p>\n

\u672c\u8a66\u9a13\u3067\u306f\u300123\u540d\u306e\u53c2\u52a0\u8005\u304c\u5b9f\u85ac\u7fa4\uff08n = 12\u3001\u5973\u602741.6%\u3001\u5e74\u9f6273.4\u00b15.0\u6b73\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n = 11\u3001\u5973\u602754.5%\u3001\u5e74\u9f6272.4\u00b17.5\u6b73\uff09\u306b\u5272\u308a\u3064\u3051\u3089\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u8a66\u9a13\u671f\u9593\u4e2d\u306b\u53c2\u52a0\u3092\u4e2d\u65ad\u3057\u305f\u306e\u306f3\u4f8b\uff08\u5b9f\u85ac\u7fa42\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa41\u4f8b\uff09\u3067\u3001\u4ecb\u8b77\u65bd\u8a2d\u3078\u306e\u5165\u6240\u3084\u3001\u5bb6\u65cf\u306e\u7814\u7a76\u53c2\u52a0\u610f\u6b32\u4f4e\u4e0b\u304c\u7406\u7531\u3067\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u983b\u5ea6\uff08\u5b9f\u85ac\u7fa441.6%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa445.5%\uff09\u304a\u3088\u3073\u8840\u6db2\u691c\u67fb\uff08\u809d\u30fb\u814e\u6a5f\u80fd\u3001\u8840\u7b97\uff09\u306b\u306f\u3001\u5b9f\u85ac\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u9593\u3067\u6709\u610f\u5dee\u3092\u8a8d\u3081\u305a\u3001\u3008\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3009\u3067\u3042\u308b\u9577\u671f\u6295\u4e0e\u306e\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u3068\u304f\u306b\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002
\n\u670d\u85ac\u7387\u306f\u5b9f\u85ac\u7fa4\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u305d\u308c\u305e\u308c77.42%\u306887.45%\u3067\u3042\u308a\u3001\u5fcd\u5bb9\u6027\u306f\u826f\u597d\u3067\u3057\u305f\u3002<\/span><\/p>\n

\u3008\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3009\u3067\u306f\u3001\u6295\u4e0e24\u9031\u6642\u70b9\u306e\u8a8d\u77e5\u75c7\u306e\u884c\u52d5\u30fb\u5fc3\u7406\u75c7\u72b6\u306e\u691c\u67fb\u30b9\u30b3\u30a2\uff08Neuropsychiatric inventory: NPI\uff09\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u6bd4\u3079\u3066\u5b9f\u85ac\u7fa4\u30670.5\u30dd\u30a4\u30f3\u30c8\u6539\u5584\u3057\u3066\u3044\u305f\u306e\u306b\u5bfe\u3057\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f0.7\u30dd\u30a4\u30f3\u30c8\u60aa\u5316\u3057\u3066\u304a\u308a\u3001\u7d71\u8a08\u5b66\u7684\u306b\u3082\u6709\u610f\u306a\u5dee\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u306a\u304a\u3001NPI\u4e0b\u4f4d\u9805\u76ee\u306e\u89e3\u6790\u3067\u306f\u3001\u300c\u6613\u6012\u6027\uff0f\u4e0d\u5b89\u5b9a\u6027\u300d\u306e\u30b9\u30b3\u30a2\u304c\u3068\u304f\u306b\u5b9f\u85ac\u7fa4\u3067\u6539\u5584\u304c\u307f\u3089\u308c\u307e\u3057\u305f<\/span>5)<\/span>\u3002<\/span><\/p>\n

\u4e3b\u89b3\u7684\u8a8d\u77e5\u969c\u5bb3\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\u306e\u4eba\u304c\u5bfe\u8c61\u306e\u8a66\u9a13\u3067\u306f\u3001\u4e00\u90e8\u306b\u5bfe\u3057\u3066\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u6291\u5236\u52b9\u679c\u304c<\/h2>\n

\u975e\u8a8d\u77e5\u75c7\u9ad8\u9f62\u8005\u3092\u5bfe\u8c61\u306b\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u300165\uff5e79\u6b73\u3067\u4e3b\u89b3\u7684\u8a8d\u77e5\u969c\u5bb3\u3001\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\u306e\u8a3a\u65ad\u57fa\u6e96\u3092\u6e80\u305f\u3059\u65b9\u3092\u5bfe\u8c61\u306b\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u9069\u683c\u57fa\u6e96\u3092\u6e80\u305f\u3059\u5bfe\u8c61\u8005\u3092\u3001\u5b9f\u85ac\u7fa4\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u3064\u3051\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269 \uff08\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3068\u3057\u3066500 mg\/\u65e5\uff09\u309296\u9031\u9593\u9023\u7d9a\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u8a8d\u77e5\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u8a55\u4fa1\u306b\u3064\u3044\u3066\u306f\u3001Alzheimer\u2019s Disease Assessment Scale-cognitive subscale (ADAS-cog)\u3001Mini-Mental State Examination (MMSE)\u3001\u304a\u3088\u3073Clinical Dementia Rating Sum of Boxes (CDR-SB)\u3068\u3044\u3046\uff13\u3064\u306e\u30b9\u30b1\u30fc\u30eb\u3092\u7528\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u3008\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3009\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e48\u9031\u5f8c\u307e\u305f\u306f96\u9031\u5f8c\u307e\u3067\u306eADAS-cog\u30b9\u30b3\u30a2\u306e\u5909\u5316\u91cf\u3001\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u305d\u306e\u4ed6\u306e\u8a8d\u77e5\u6a5f\u80fd\u691c\u67fb\u306e\u5909\u5316\u91cf\u3092\u542b\u3081\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u672c\u7814\u7a76\u306f\u91d1\u6ca2\u5927\u5b66\u533b\u5b66\u502b\u7406\u5be9\u67fb\u59d4\u54e1\u4f1a\uff088013\u53f7\uff09\u306e\u627f\u8a8d\u3092\u53d7\u3051\u3066\u5b9f\u65bd\u3057\u307e\u3057\u305f\uff08\u81e8\u5e8a\u8a66\u9a13\u767b\u9332\uff1ajRCTs 041180064\uff0fUMIN 000021596\uff09\u3002<\/span><\/p>\n

 <\/p>\n

\u672c\u8a66\u9a13\u3067\u306f\u3001323\u540d\u306e\u53c2\u52a0\u8005\u304c\u5b9f\u85ac\u7fa4\uff08n = 162\u3001\u5973\u602765.4%\u3001\u5e74\u9f6271.5\u00b14.1\u6b73\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n = 161\u3001\u5973\u602764.5%\u3001\u5e74\u9f6271.6\u00b14.2\u6b73\uff09\u306b\u5272\u308a\u3064\u3051\u3089\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n

\u8a66\u9a13\u671f\u9593\u4e2d\u306b\u53c2\u52a0\u3092\u4e2d\u65ad\u3057\u305f\u306e\u306f47\u4f8b\uff08\u5b9f\u85ac\u7fa422\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa425\u4f8b\uff09\u3067\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u3008\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3009\u306eADAS-cog\u30b9\u30b3\u30a2\u306e\u5909\u5316\u91cf\u306b\u3064\u3044\u3066\u306f\u3001\u5b9f\u85ac\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u6709\u610f\u306a\u5dee\u3092\u898b\u51fa\u3059\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n

\u3008\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3009\u306eMMSE\u3068CDR-SB\u306b\u3064\u3044\u3066\u3082\u3001\u53c2\u52a0\u8005\u5168\u4f53\u3067\u306f\u5b9f\u85ac\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u9593\u3067\u6709\u610f\u5dee\u306f\u898b\u51fa\u305b\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u9ad8\u8840\u5727\u306e\u306a\u3044\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u306f\u300196\u9031\u6642\u70b9\u306b\u304a\u3051\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306eCDR-SB\u30b9\u30b3\u30a2\u306e\u5909\u5316\u91cf\u306b\u3064\u3044\u3066\u3001\u5b9f\u85ac\u7fa4\u306e\u30b9\u30b3\u30a2\u306f0.006\u6539\u5584\u3057\u3066\u3044\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u30b9\u30b3\u30a2\u304c0.085\u60aa\u5316\u3057\u3066\u304a\u308a\u3001\u6709\u610f\u306b\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u6291\u5236\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f<\/span>6)<\/span>\u3002<\/span><\/p>\n

\u5b89\u5168\u3067\u5b89\u4fa1\u306a\u8a8d\u77e5\u75c7\u4e88\u9632\u3068\u3057\u3066\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u304c\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b<\/h2>\n

\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306f\u3001\u4e00\u822c\u306b\u6297\u9178\u5316\u4f5c\u7528\u304c\u5f37\u304f\u3001\u52d5\u8108\u786c\u5316\u306a\u3069\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u306b\u5f79\u7acb\u3064\u6a5f\u80fd\u6027\u6210\u5206\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u4eca\u56de\u308f\u305f\u3057\u305f\u3061\u304c\u6ce8\u76ee\u3057\u305f\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306f\u3001\u53e4\u304f\u304b\u3089\u6b27\u5dde\u3067\u85ac\u7528\u690d\u7269\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u30ed\u30fc\u30ba\u30de\u30ea\u30fc\u3084\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u3068\u3044\u3063\u305f\u30cf\u30fc\u30d6\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3067\u3042\u308a\u3001\u6297\u9178\u5316\u3001\u6297\u708e\u75c7\u3001\u6297\u7d30\u83cc\u3001\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u6709\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

 <\/p>\n

\u6700\u8fd1\u3001\u308f\u305f\u3057\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3092\u6442\u53d6\u3057\u305f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u52d5\u7269\u3067\u306f\u3001\u8133\u5185\u306b\u304a\u3044\u3066\u30c9\u30fc\u30d1\u30df\u30f3\u95a2\u9023\u306e\u30e2\u30ce\u30a2\u30df\u30f3\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u305d\u308c\u3089\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8133\u5185\u306b\u7570\u5e38\u306b\u84c4\u7a4d\u3059\u308b\u300c\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u305f\u3093\u3071\u304f\u300d\u306e\u51dd\u96c6\u3092\u6291\u5236\u3059\u308b\u3053\u3068<\/span>7)<\/span>\u3002
\n<\/span>\u305d\u3057\u3066\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30e2\u30c7\u30eb\u52d5\u7269\u306ec-Jun N-terminal kinase (JNK)\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u6291\u5236\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u8133\u5185\u3067\u7570\u5e38\u84c4\u7a4d\u3059\u308b\u3082\u3046\u4e00\u3064\u306e\u305f\u3093\u3071\u304f\u3067\u3042\u308b\u300c\u30bf\u30a6\u305f\u3093\u3071\u304f\u300d\u306e\u30ea\u30f3\u9178\u5316\u6291\u5236\u3001\u304a\u3088\u3073\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f<\/span>8)<\/span>\u3002<\/span><\/p>\n

\u307e\u305f\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u306f\u3001\u9577\u671f\u9593\u6442\u53d6\u3057\u3066\u3082\u5b89\u5168\u3067\u5fcd\u5bb9\u6027\u304c\u9ad8\u304f\u3001\u975e\u9ad8\u8840\u5727\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u6291\u5236\u52b9\u679c\u3092\u6301\u3064\u306e\u307f\u306a\u3089\u305a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3067\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u884c\u52d5\u30fb\u5fc3\u7406\u75c7\u72b6\u306e\u4f4e\u6e1b\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

 <\/p>\n

\u4eca\u5f8c\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u6297\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u3001\u98df\u306b\u3088\u308b\u5b89\u5168\u3067\u5b89\u4fa1\u306a\u75be\u75c5\u4e88\u9632\u3001\u751f\u4f53\u6052\u5e38\u6027\u7dad\u6301\u306b\u5927\u304d\u304f\u8ca2\u732e\u3067\u304d\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n

 <\/p>\n

\u6700\u5f8c\u306b\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u3054\u53c2\u52a0\u3044\u305f\u3060\u3044\u305f\u7686\u69d8\u306a\u3089\u3073\u306b\u3001\u8a66\u9a13\u98df\u54c1\u3092\u7121\u511f\uff0f\u6709\u511f\u306b\u3066\u3054\u63d0\u4f9b\u3044\u305f\u3060\u3044\u305f\u4e38\u5584\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u306b\u539a\u304f\u5fa1\u793c\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002
\n\u7b2cI\u76f8\uff5e\u7b2cIII\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u5b9f\u65bd\u306b\u969b\u3057\u3066\u3001\u3054\u5354\u529b\u306a\u3089\u3073\u306b\u3054\u6307\u5c0e\u304f\u3060\u3055\u3063\u305f\u56fd\u5bb6\u516c\u52d9\u54e1\u5171\u6e08\u7d44\u5408\u9023\u5408\u4f1a\u4e5d\u6bb5\u5742\u75c5\u9662\u306e\u5c71\u7530\u6b63\u4ec1\u5148\u751f\u3068\u3001\u91d1\u6ca2\u5927\u5b66\u8133\u795e\u7d4c\u5185\u79d1\u306e\u5148\u751f\u65b9\u3001\u5fc3\u7406\u5e2b\u306e\u7686\u69d8\u3001\u305d\u306e\u4ed6\u3054\u5354\u529b\u304f\u3060\u3055\u3063\u305f\u3059\u3079\u3066\u306e\u7686\u69d8\u306b\u611f\u8b1d\u306e\u610f\u3092\u8868\u3057\u307e\u3059\u3002<\/span><\/p>\n

\n

\u3010\u53c2\u8003\u6587\u732e\u3011<\/span><\/p>\n

1) <\/span>Ono K, Hasegawa K, Naiki H, et al. Curcumin has potent anti-amyloidogenic effects for Alzheimer\u2019s beta-amyloid fibrils in vitro. J Neurosci Res 75, 742\u201350, 2004.\u00a0<\/span><\/p>\n

2)<\/span> Ono K, Li L, Takamura Y, et al. Phenolic compounds prevent amyloid \u03b2-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem 287, 14631\u201343, 2012.\u00a0<\/span><\/p>\n

3)<\/span> Hamaguchi T, Ono K, Murase A, et al. Phenolic compounds prevent Alzheimer\u2019s pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol 175, 2557\u201365, 2009.\u00a0<\/span><\/p>\n

4) <\/span>Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. PLoS One 10, e0126422, 2015.\u00a0<\/span><\/p>\n

5)<\/span> <\/span>Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer\u2019s disease progression. Sci Rep 10, 18627, 2020.<\/span><\/p>\n

6)<\/span> Noguchi-Shinohara M, Hamaguchi T, Sakai K, et al. Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled Trial. J Alzheimer\u2019s dis, online ahead of print. doi: 10.3233\/JAD-220953<\/span><\/p>\n

7)<\/span> <\/span>Hase T, Shishido S, Yamamoto S, et al. Rosmarinic acid suppresses Alzheimer\u2019s disease development by reducing amyloid beta aggregation by increasing monoamine secretion. Sci Rep, 9, 8711, 2019.<\/span><\/p>\n

8) <\/span>Yamamoto S, Noguchi-Shinohara M, Hamaguchi T, et al. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. npj Science of Food. 5, 1, 2021.<\/span><\/p>\n

\n

\u91d1\u6ca2\u5927\u5b66 \u533b\u85ac\u4fdd\u5065\u7814\u7a76\u57df\u533b\u5b66\u7cfb \u8133\u795e\u7d4c\u5185\u79d1\u5b66
\n<\/span>\u7be0\u539f\u3082\u3048\u5b50 \u5148\u751f\u3001\u5c0f\u91ce\u8ce2\u4e8c\u90ce \u5148\u751f<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u6297\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u52b9\u679c\u3092\u5f37\u304f\u793a\u3057\u305f\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u304c\u3042\u308b \u8a8d\u77e5\u75c7\u306e\u539f\u56e0\u75be […]<\/p>\n","protected":false},"author":144,"featured_media":71958,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75,43],"tags":[405,404],"class_list":["post-71904","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-doctors","category-interview","tag-d00055","tag-d00054"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/posts\/71904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/users\/144"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/comments?post=71904"}],"version-history":[{"count":3,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/posts\/71904\/revisions"}],"predecessor-version":[{"id":96906,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/posts\/71904\/revisions\/96906"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/media\/71958"}],"wp:attachment":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/media?parent=71904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/categories?post=71904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu\/wp-json\/wp\/v2\/tags?post=71904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}