{"id":22833,"date":"2022-07-01T10:53:19","date_gmt":"2022-07-01T01:53:19","guid":{"rendered":"https:\/\/www.mcsg.co.jp\/kentatsu\/?p=22833"},"modified":"2026-05-18T14:47:42","modified_gmt":"2026-05-18T05:47:42","slug":"%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e5%9e%8b%e8%aa%8d%e7%9f%a5%e7%97%87%e3%81%ae%e4%ba%88%e9%98%b2%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"interview","link":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/interview\/22833","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u306b\u3064\u3044\u3066\u00a0"},"content":{"rendered":"

\u91d1\u6ca2\u5927\u5b66\u533b\u85ac\u4fdd\u5065\u7814\u7a76\u57df\u533b\u5b66\u7cfb\u3000\u8133\u795e\u7d4c\u5185\u79d1\u5b66<\/span>\u00a0<\/span><\/p>\n

\u5c0f\u91ce\u8ce2\u4e8c\u90ce<\/span> \u5148\u751f<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/b>\u201c\u8a8d\u77e5\u75c71<\/span><\/b>000<\/span><\/b>\u4e07\u4eba\u6642\u4ee3\u201d\u304c\u3084\u3063\u3066\u304f\u308b<\/span><\/b><\/h2>\n

\u00a0<\/span>\u308f\u304c\u56fd\u3067\u306f\u9ad8\u9f62\u5316\u306e\u9032\u884c\u304c\u65e9\u307e\u308a\u3001\u8d85\u9ad8\u9f62\u793e\u4f1a\u3078\u7a81\u5165\u3057\u3066\u3044\u307e\u3059\u3002
\n\u8a8d\u77e5\u75c7\u306e\u60a3\u8005\u6570\u306f<\/span>2012\u5e74\u306b\u7d04462\u4e07\u4eba\u30012025\u5e74\u306b\u7d04675\u4e07\u4eba\u30012050\u5e74\u306b\u306f1000\u4e07\u4eba\u3092\u4e0a\u56de\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066<\/span>\u304a\u308a\u3001<\/span>2012\u5e74\u306b\u306f\u539a\u751f\u52b4\u50cd\u7701\u306e\u65bd\u7b56\u3068\u3057\u3066\u300c\u8a8d\u77e5\u75c7\u65bd\u7b56\u63a8\u90325\u304b\u5e74\u8a08\u753b\uff08\u30aa\u30ec\u30f3\u30b8\u30d7\u30e9\u30f3\uff09\u300d\u304c\u7b56\u5b9a\u3055\u308c\u3001\u65e9\u671f\u8a3a\u65ad\u30fb\u65e9\u671f\u5bfe\u5fdc\u306b\u5411\u3051\u305f\u53d6\u308a\u7d44\u307f\u304c\u9032\u3081\u3089\u308c<\/span>\u307e\u3057\u305f\u3002
\n2019\u5e74\u306b\u306f\u3001\u8a8d\u77e5\u75c7\u65bd\u7b56\u63a8\u9032\u5927\u7db1\u304c\u53d6\u308a\u307e\u3068\u3081\u3089\u308c\u3001\u300c\u8a8d\u77e5\u75c7\u306f\u3060\u308c\u3082\u304c\u306a\u308a\u3046\u308b\u3082\u306e\u300d\u3068\u660e\u8a18\u3055\u308c\u3001<\/span>\u201c<\/span>\u5171\u751f<\/span>\u201d<\/span>\u3068<\/span>\u201c<\/span>\u4e88\u9632<\/span>\u201d<\/span>\u304c\u5bfe\u7b56\u306e\u4e21\u8f2a\u3068\u3055\u308c\u307e\u3057\u305f<\/span>(*1)(*2)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u201c<\/span>\u8a8d\u77e5\u75c7<\/span>1000\u4e07\u4eba\u6642\u4ee3\u201d<\/span>\u3092\u8fce\u3048\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u73fe\u5728\u3001\u8a8d\u77e5\u75c7\u3092\u4e88\u9632\u3059\u308b\u305f\u3081\u306b\u306f\u4f55\u3092\u3057\u305f\u3089\u3088\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f
\n\u672c\u30b3\u30e9\u30e0\u3067\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u306b\u3064\u3044\u3066\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3092\u4e2d\u5fc3\u306b\u8ff0\u3079\u305f\u3044\u3068\u601d\u3044\u307e\u3059<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

<\/b>\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u305f\u3081\u306b\u4fee\u6b63\u53ef\u80fd\u306a<\/span><\/b>\u201c<\/span><\/b>\u5f8c\u5929\u7684\u56e0\u5b50\u201d\u304c\u3042\u308b<\/span><\/b><\/h2>\n

\u4e88\u9632\u306e\u305f\u3081\u306e\u4fee\u6b63\u53ef\u80fd\u306a\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u3001\uff08\u4e2d\u5e74\u671f\uff09\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3001\u55ab\u7159\u3001\u8eab\u4f53\u6d3b\u52d5\u3001\u3046\u3064\u75c5\u304c\u3042\u3052\u3089\u308c\u307e\u3059<\/span>(*3)(*4)(*5)(*6\uff09<\/span>\u3002<\/span><\/p>\n

\u9ad8\u8840\u5727\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3078\u306e\u5bc4\u4e0e\u7387\u306f<\/span>5.1\uff05\u3067<\/span>\u3059\u3002
\n\u8a8d\u77e5\u75c7\u4e88\u9632\u306e\u89b3\u70b9\u304b\u3089<\/span>\u3001<\/span>\u9ad8\u8840\u5727\u306e\u6cbb\u7642\u306f\u7a4d\u6975\u7684\u306b\u884c\u3046\u3079\u304d\u3067\u3042\u308b\u3068\u3044\u3048\u307e\u3059<\/span>(*6)(*7)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u7cd6\u5c3f\u75c5\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3060\u3051\u3067\u306a\u304f\u3001\u8840\u7ba1\u6027\u8a8d\u77e5\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3067\u3082\u3042\u308a\u307e\u3059\u3002
\n\u7279\u306b\u4e2d\u5e74\u671f\u306e\u8840\u7cd6\u7ba1\u7406\u306f<\/span>\u3001<\/span>\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u4e88\u9632\u306b\u5fc5\u8981\u3067\u3059<\/span>(*6)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u4e2d\u5e74\u671f\u306e\u8102\u8cea\u7570\u5e38\u75c7\u306f<\/span>\u3001<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u308a\u3001\u7279\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u53b3\u683c\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3067\u3057\u3087\u3046<\/span>(*6)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u904b\u52d5\u4e0d\u8db3\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u3078\u306e\u5bc4\u4e0e\u7387\u304c<\/span>12.7\uff05\u3068\u9ad8\u304f\u3001\u5b9a\u671f\u7684\u306a\u8eab\u4f53\u6d3b\u52d5\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u3092\u6291\u5236\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044<\/span>\u307e\u3059<\/span>(*6)(*7)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

<\/b>\u98df\u4e8b\u304c\u8a8d\u77e5\u75c7\u4e88\u9632\u306b\u3082\u305f\u3089\u3059\u52b9\u679c<\/span><\/b><\/h2>\n

\u00a0<\/span>\u3053\u3053\u304b\u3089\u306f\u3001\u98df\u4e8b\u3068\u8a8d\u77e5\u75c7\u4e88\u9632\u3068\u306e\u95a2\u9023\u6027\u306b\u3064\u3044\u3066\u3001\u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u5831\u544a\u3092\u4ea4\u3048\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/span><\/p>\n

\u3010\u2460<\/span><\/b>\u7dd1\u8336<\/span><\/b>\u3011<\/span><\/b>\u00a0<\/span><\/h3>\n

\u77f3\u5ddd\u770c\u4e03\u5c3e\u5e02\u306e\u4e2d\u5cf6\u753a\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u7dd1\u8336\u306e\u6442\u53d6\u983b\u5ea6\u304c\u591a\u3044\u8a8d\u77e5\u6a5f\u80fd\u6b63\u5e38\u306e\u9ad8\u9f62\u8005\u7fa4\u3067\u306f\u3001\u7dd1\u8336\u3092\u98f2\u307e\u306a\u3044\u7fa4\u3068\u6bd4\u3079\u3066\u3001\u7d04<\/span>5\u5e74\u5f8c\u306b\u8a8d\u77e5\u75c7\u3084\u305d\u306e\u524d\u6bb5\u968e\u3068\u3055\u308c\u308b\u300c<\/span>\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3<\/span>\u300d<\/span>\u306b\u9032\u5c55\u3059\u308b\u5272\u5408\u304c<\/span>\u3001<\/span>\u7d043\u5206\u306e1\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f<\/span>(*8)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u540c\u69d8\u306b\u5bae\u57ce\u770c\u3067\u884c\u308f\u308c\u305f\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3082\u3001\u7dd1\u8336\u6442\u53d6\u306f\u5c06\u6765\u306e\u8a8d\u77e5\u75c7\u767a\u75c7\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u304c\u898b\u3089\u308c\u307e\u3057\u305f<\/span>(*9)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u3010\u2461<\/span><\/b>\u30d3\u30bf\u30df\u30f3<\/span><\/b>C\u3011<\/span><\/b>\u00a0<\/span><\/h3>\n

\u8102\u8cea\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b<\/span>\u300c<\/span>\u30a2\u30dd\u30ea\u30dd\u30d7\u30ed\u30c6\u30a4\u30f3<\/span> E\u907a\u4f1d\u5b50 (APOE) \u025b 4\u300d<\/span>\u306f<\/span>\u3001<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u767a\u75c7\u306e\u3082\u3063\u3068\u3082\u5f37\u529b\u306a\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059<\/span>(*10)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u4e2d\u5cf6\u753a\u7814\u7a76\u3067\u306f<\/span>\u3001APOE\u03b54\u30a2\u30ea\u30eb\u3092\u4fdd\u6709\u3059\u308b\u6b63\u5e38\u8a8d\u77e5\u6a5f\u80fd\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u3001<\/span>\u8840\u4e2d\u30d3\u30bf\u30df\u30f3C\u6fc3\u5ea6\u304c\u4e09\u5206\u4f4d\u306e\u3082\u3063\u3068\u3082\u9ad8\u3044\u7fa4\u306f<\/span>\u3001<\/span>\u3082\u3063\u3068\u3082\u4f4e\u3044\u7fa4\u3068\u6bd4\u3079\u3066<\/span>\u3001<\/span>\u5c06\u6765\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\uff08\u8a8d\u77e5\u75c7\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\uff09\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c10\u5206\u306e1\u306b\u306a\u308a\u307e\u3057\u305f\u3002
\n\u3053\u306e\u3053\u3068\u3088\u308a<\/span>\u3001APOE\u03b54\u4fdd\u6709\u5973\u6027\u306b\u304a\u3044\u3066\u3001<\/span>\u30d3\u30bf\u30df\u30f3C\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c<\/span>\u3001<\/span>\u5c06\u6765\u306e\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f<\/span>(*11)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u3010\u2462<\/span><\/b>\u6b8b\u5b58\u6b6f\u6570<\/span><\/b>\u3011<\/span><\/b>\u00a0<\/span><\/h3>\n

\u4e2d\u5cf6\u753a\u7814\u7a76\u3067\u306f<\/span>\u3001<\/span>\u6b8b\u5b58\u6b6f\u6570\u304c\u591a\u3044\u3053\u3068\u3068\u95a2\u9023\u3059\u308b\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\uff08\u6b8b\u5b58\u6b6f\u6570\u95a2\u9023\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\uff09\u304c\u3042\u308b\u3053\u3068\u3082\u898b\u51fa\u3057\u3066\u3044\u307e\u3059<\/span>(*12)<\/span>\u3002
\n\u6b8b\u5b58\u6b6f\u6570\u95a2\u9023\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u306f\u3001<\/span>\u300c<\/span>\u7dd1\u9ec4\u8272\u91ce\u83dc\u3001\u8449\u91ce\u83dc\u306e\u6442\u53d6\u304c\u591a\u304f\u3001\u7c73\u306e\u6442\u53d6\u304c\u5c11\u306a\u3044<\/span>\u300d<\/span>\u3068\u3044\u3046\u7279\u5fb4\u304c\u898b\u3089\u308c\u3001\u3053\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u3088\u304f\u53d6\u308a\u5165\u308c\u3066\u3044\u308b\u7fa4\u3067\u306f\u3001\u307b\u3068\u3093\u3069\u53d6\u308a\u5165\u308c\u3066\u3044\u306a\u3044\u7fa4\u306b\u6bd4\u3079\u3066<\/span>\u3001<\/span>\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\uff08\u8a8d\u77e5\u75c7\u307e\u305f\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\uff09\u306e\u30aa\u30c3\u30ba\u6bd4\u306f0.43\u3067\u3057\u305f<\/span>(*12)<\/span>\u3002<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

<\/b>\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306b\u3088\u308b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u4e88\u9632\u6cd5\u306e\u958b\u767a\u7814\u7a76<\/span><\/b><\/h2>\n

\u00a0<\/span>\u7b46\u8005\u81ea\u8eab\u3082\u3001\u3055\u307e\u3056\u307e\u306a\u75ab\u5b66\u7684\u5831\u544a\u306b\u57fa\u3065\u304d\u3001\u7dd1\u8336\u3084\u8d64\u30ef\u30a4\u30f3\u306a\u3069\u306b\u542b\u307e\u308c\u308b\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u985e\u306b\u6ce8\u76ee\u3057\u3066<\/span>\u3001<\/span>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u30fb\u6cbb\u7642\u6cd5\u958b\u767a\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3002<\/span>\u00a0<\/span><\/p>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306e\u4e3b\u75c5\u614b\u306f<\/span>\u3001<\/span>\u8133\u306e<\/span>\u300c<\/span>\u30a2\u30df\u30ed\u30a4\u30c9<\/span>\u03b2(\u30d9\u30fc\u30bf)\u86cb(\u305f\u3093)\u767d(\u3071\u304f)\uff08A\u03b2\uff09\u300d<\/span>\u306e\u51dd\u96c6\u30fb\u6c88\u7740\u3067\u3059\u3002
\n\u6211\u3005\u306f\u3001\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u3067\u3042\u308b\u30df\u30ea\u30bb\u30c1\u30f3\u3084\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306f\u3001\u8a66\u9a13\u7ba1\u5185\u3067A\u03b2\u306b\u7d50\u5408\u3057\u3066A\u03b2\u306e\u51dd\u96c6\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u6bd2\u6027\u3092\u8efd\u6e1b\u3055\u305b\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f<\/span>(*13)(*14)<\/span>\u3002
\n\u3055\u3089\u306b\u3001\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u3053\u308c\u3089\u306e\u30d5\u30a7\u30ce\u30fc\u30eb\u5316\u5408\u7269\u3092\u7d4c\u53e3\u6442\u53d6\u3055\u305b\u305f\u3068\u3053\u308d\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u306f\u8133\u5185\u306e\u4e0d\u6eb6\u6027\u306eA\u03b2\u6c88\u7740\u3060\u3051\u3067\u306a\u304f\u3001\u6bd2\u6027\u306e\u3088\u308a\u9ad8\u3044\u53ef\u6eb6\u6027A\u03b2\u30aa\u30ea\u30b4\u30de\u30fc\u3082\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f<\/span>(*15)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u307e\u305f\u3001\u6211\u3005\u306e\u7814\u7a76\u3067\u306f\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u3092\u7528\u3044\u3066\u3001\u5065\u5e38\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30ed\u30b9\u30de\u30ea\u30f3\u9178\uff08<\/span>500 mg\uff09\u542b\u6709\u30ec\u30e2\u30f3\u30d0\u30fc\u30e0\u62bd\u51fa\u7269\u306e\u5358\u56de\u6295\u4e0e\u306e\u5b89\u5168\u6027\u30fb\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u78ba\u8a8d\u3057<\/span>(*16)<\/span>\u3001\u8efd\u5ea6\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u65bd\u884c\u3057\u305f\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13\u306b\u3066<\/span>\u3001<\/span>\u795e\u7d4c\u7cbe\u795e\u75c7\u72b6\u306e\u60aa\u5316\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f<\/span>(*17)<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u00a0<\/span><\/b>\u98df\u4e8b\u3068\u904b\u52d5\u3001\u305d\u3057\u3066\u751f\u6d3b\u7fd2\u6163\u75c5\u4e88\u9632\u3092\u610f\u8b58\u3057\u3088\u3046<\/span><\/b><\/h2>\n

\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\u306b\u304a\u3051\u308b\u767a\u75c7\u4e88\u9632\u306e\u305f\u3081\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u98df\u4e8b\u3068\u904b\u52d5\u306b\u6c17\u3092\u3064\u3051\u306a\u304c\u3089\u306e\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u5bfe\u7b56\u3092\u610f\u8b58\u3057\u305f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u304c\u5927\u5207\u3067\u3059\u3002
\n\u4eca\u5f8c\u3001\u8a8d\u77e5\u75c7\u4e88\u9632\u3092\u5ff5\u982d\u306b\u304a\u3044\u305f\u30b3\u30db\u30fc\u30c8\u304a\u3088\u3073\u57fa\u790e\u7814\u7a76\u306e\u4e21\u9762\u306e\u63a8\u9032\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u3044\u3048\u307e\u3059<\/span>\u3002<\/span>\u00a0<\/span><\/p>\n

\u3010\u53c2\u8003\u6587\u732e<\/span>\u3011<\/span>\u00a0<\/span><\/p>\n

*1)<\/span> \u4e38\u5c71\u535a\u6587\uff0e\u8a8d\u77e5\u75c7\u3078\u306e\u5bfe\u5fdc\u306e\u3053\u308c\u307e\u3067\u3068\u3053\u308c\u304b\u3089\uff0e\u65e5\u672c\u5185\u79d1\u5b66\u4f1a\u96d1\u8a8c\u3000109\uff1a1501-1503\uff0e<\/span>\u00a0<\/span><\/p>\n

*2)<\/span> \u8a8d\u77e5\u75c7\u65bd\u7b56\u63a8\u9032\u5927\u7db1\uff0e\u4ee4\u548c\u5143\u5e746\u670818\u65e5\uff0e<\/span>https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/0000076236_00002.html<\/span>\u00a0<\/span><\/p>\n

*3)<\/span> <\/span>Deckers K, van Boxtel MP, Schiepers OJ, et al. Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies. Int J Geriatr Psychiatry 30: 234-246, 2015.\u00a0<\/span>\u00a0<\/span><\/p>\n

*4)<\/span> Beydoun MA, Beydoun HA, Gamaldo AA, et al. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health 14:643, 2014.<\/span>\u00a0<\/span><\/p>\n

*5)<\/span> Plassman BL, Williams JW Jr, Burke JR, et al. Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Ann Intern Med 153: 182-193, 2010.\u00a0<\/span>\u00a0<\/span><\/p>\n

*6) <\/span>\u7d4c\u904e\u3068\u6cbb\u7642\u3000\u8a8d\u77e5\u75c7\u5371\u967a\u56e0\u5b50\u30fb\u9632\u5fa1\u56e0\u5b50\u3000\u8a8d\u77e5\u75c7\u306e\u5371\u967a\u56e0\u5b50\u30fb\u9632\u5fa1\u56e0\u5b50\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308b\u304b\uff0e \u8a8d\u77e5\u75c7\u75be\u60a3\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f32017 pp118-120, \u65e5\u672c\u795e\u7d4c\u5b66\u4f1a\u76e3\u4fee\uff0c\u533b\u5b66\u66f8\u9662\uff0c\u6771\u4eac\uff0c2017.<\/span>\u00a0<\/span><\/p>\n

*7)<\/span> Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 10: 819-828, 2011.\u00a0<\/span>\u00a0<\/span><\/p>\n

*8)<\/span> Noguchi-Shinohara M, Yuki S, et al. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS ONE 9: e96013, 2014.<\/span>\u00a0<\/span><\/p>\n

*9)<\/span> Tomata Y, Sugiyama K, Kaiho Y, et al. Green Tea Consumption and the Risk of Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. Am J Geriatr Psychiatry 24: 881-889, 2016.<\/span>\u00a0<\/span><\/p>\n

*10)<\/span> Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet 45: 1452-1458, 2013.<\/span>\u00a0<\/span><\/p>\n

*11) <\/span>Noguchi-Shinohara M, Abe C, Yuki-Nozaki S, et al. Higher blood vitamin C levels are associated with reduction of apolipoprotein E E4-related risks of cognitive decline in women: the Nakajima study. J Alzheimers Dis 63: 1289-1297, 2018.<\/span>\u00a0<\/span><\/p>\n

*12)<\/span> Ishimiya M, Nakamura H, Kobayashi Y, et al. Tooth loss-related dietary patterns and cognitive impairment in an elderly Japanese population: the Nakajima study. PLoS ONE 13: e0194504, 2018.<\/span>\u00a0<\/span><\/p>\n

*13)<\/span> Ono K, Li L, Takamura Y, et al. Phenolic compounds prevent amyloid \u03b2-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem 287: 14631-14643, 2012.<\/span>\u00a0<\/span><\/p>\n

*14) <\/span>Watanabe-Nakayama T, Ono K, Itami M, et al. High-speed atomic force microscopy reveals structural dynamics of amyloid \u03b21-42 aggregates. Proc Natl Acad Sci USA 113: 5835-5840, 2016.<\/span>\u00a0<\/span><\/p>\n

*15)<\/span> Hamaguchi T, Ono K, Murase A, et al. Phenolic compounds prevent Alzheimer’s pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol 175: 2557-2565, 2009.<\/span>\u00a0<\/span><\/p>\n

*16)<\/span> Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial. PLoS One 10: e0126422, 2015.<\/span>\u00a0<\/span><\/p>\n

*17)<\/span> Noguchi-Shinohara M, Ono K, Hamaguchi T, et al. Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer’s disease progression. Sci Rep 10: 18627, 2020.<\/span>\u00a0<\/span><\/p>\n","protected":false},"author":17,"featured_media":22836,"template":"","interview_cat":[1486],"expert":[1350],"class_list":["post-22833","interview","type-interview","status-publish","has-post-thumbnail","hentry","interview_cat-doctors","expert-d00022"],"_links":{"self":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/interview\/22833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/interview"}],"about":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/types\/interview"}],"author":[{"embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/users\/17"}],"version-history":[{"count":4,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/interview\/22833\/revisions"}],"predecessor-version":[{"id":47252,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/interview\/22833\/revisions\/47252"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/media\/22836"}],"wp:attachment":[{"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/media?parent=22833"}],"wp:term":[{"taxonomy":"interview_cat","embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/interview_cat?post=22833"},{"taxonomy":"expert","embeddable":true,"href":"https:\/\/www.mcsg.co.jp\/kentatsu_stg\/wp-json\/wp\/v2\/expert?post=22833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}